10TH CONGRESS
OF THE BRAZILIAN INSTITUTE OF NEUROSCIENCE AND NEUROTECHNOLOGY (BRAINN)
April 03 - 05
2024
School of Medical Sciences - Unicamp
Speakers
in alphabetical order
Mariana Bento
Assistant Professor, Schulich School of Engineering, University of Calgary
#brainabnormalities #MRimaging #deeplearning #medicalimaging
“Better” Machine Learning for Brain Imaging Studies
Lecture on Thursday, April 4th, 10:00am to 11:00am
Machine learning (ML) and computer vision strategies have been largely used for brain imaging applications: providing screening/triage tools; supporting patients’ diagnosis; assisting experts in the decision-making and selection of treatment options. Such models learn data patterns from larger datasets and then can be used for personalized decision-making using new subject data. However, there is a challenge in translating ML models for real-world applications, limiting the usage of such tools outside research related to model reliability and robustness. My main goal is to develop “better” machine learning algorithms. My definition of “better” considers not only accurate findings but also factors like fairness, interpretability, and transparency, aiming to develop trustworthy models. Such models consider and mitigate multiple sources of bias related to demographic variables, imbalance in terms of the number of patients per pathology, or singlesource parameters (bias related to the usage of a single data source with the research particularities, such as specific acquisition settings or protocols).
Mariana Bento, PhD is a Faculty in the Department of Biomedical Engineering in the Schulich School of Engineering at the University of Calgary, with joint appointment in the Department of Electrical and Software Engineering (ESE). I have been working in the development of Artificial Intelligence (AI) tools for healthcare applications for over 10 years. Over this time, Dr. Bento developed unique strategies for synthesizing ML, especially Deep Learning (DL) models considering imaging variability, large and heterogeneous datasets, ML interpretability, and domain adaptation approaches. She is the Principal Investigator of the NSERC Discovery Grant “Translation of Machine Leaning Methods for Brain Magnetic Resonance Imaging to Heterogeneous Datasets: Bridging the Gap to Generalizable Models” and NSERC AI Alliance “Trustworthy AI for Healthcare Applications”. Dr. Bento program focus on Artificial Intelligence for Healthcare applications, considering key aspects like responsibility, trustworthiness, fairness, and bias mitigation; considering biases related to varying demographics and heterogeneous data (variability related to acquisition protocols).
Mariana Bento é Professora Assistente na Universidade de Calgary, Canadá. Anteriormente, atuou como Pós-doutoranda em Radiologia e Neurociência Clínica na Universidade de Calgary. Fez Doutorado (2016) na Faculdade de Engenharia Elétrica e de Computação da Universidade de Campinas, com estágio na Universidade de Calgary, e Mestrado (2013) na mesma faculdade, com estágio na Universidade da Pensilvânia. Concluiu o Bacharelado em Engenharia de Teleinformática como a primeira da turma na Universidade Federal do Ceará (2011). Desde 2011, trabalha com machine learning e deep learning para imagens médicas. Os tópicos de interesse são anormalidades cerebrais, conjuntos de dados heterogêneos, avaliação da qualidade de imagens de ressonância magnética e interpretação de abordagens de deep learning em aplicações de imagens médicas.
Gabriela Castellano
Evaluation of brain changes due to rehabilitation training with XR and BCIs
Lecture on Friday, April 5th, 09:40am to 10:20am
Since 2004, she has been a professor at the Gleb Wataghin Institute of Physics at UNICAMP. Since 2019, she has been the extension coordinator at IFGW.
Since 2005, she has been part of the Neurophysics Group at UNICAMP, specializing in static and functional MR spectroscopy, texture analysis of anatomical MR images, studies on brain connectivity based on functional MR images and electroencephalography signals, brain-machine interfaces, and the development and evaluation of assistive and motor function rehabilitation techniques.
She was a researcher for the CInAPCe Program (Interinstitutional Cooperation in Support of Brain Research) from 2007 to 2013 and the DesTINe project (Development of Information Technologies for Neurology) from 2010 to 2014.
She was the coordinator of the XTReMe project (eXperiences of Rehabilitation Technologies in Medicine) from 2016 to 2019.
She is the co-principal investigator of the CEPID BRAINN (Brazilian Institute of Neuroscience and Neurotechnology).
Desde 2004, é professora do Instituto de Física Gleb Wataghin da UNICAMP. Desde 2019, é coordenadora de extensão do IFGW.
Desde 2005, faz parte do Grupo de Neurofísica da UNICAMP, com atuação em: espectroscopia de RM ‘estática’ e funcional, análise de textura de imagens de RM anatômicas, estudos de conectividade cerebral baseados em imagens de RM funcionais e sinais de eletroencefalografia, interfaces cérebro-máquina, desenvolvimento e avaliação de técnicas assistivas e de reabilitação de funções motoras.
Foi pesquisadora do Programa CInAPCe (Cooperação Interinstitucional de Apoio a Pesquisas sobre o Cérebro) (2007-2013), e do projeto DesTINe (Desenvolvimento de Tecnologias de Informação para Neurologia) (2010-2014).
Foi coordenadora do projeto XTReMe (eXperiências de Tecnologias de Reabilitação em Medicina) (2016-2019).
Co-pesquisadora principal do CEPID BRAINN (Brazilian Institute of Neuroscience and Neurotechnology).
Fernando Cendes
Full Professor in the Department of Neurology at UNICAMP.
In 1997, he joined as a physician and lecturer at the Faculty of Medical Sciences of Unicamp.
He is a visiting professor at McGill University, Department of Neurology and Neurosurgery (since 1997), and was one of the coordinators of the health area at FAPESP (2007-2021).
He was the president of the Brazilian League of Epilepsy (2006-2008), secretary of the Neuroimaging Subcommittee of the International League Against Epilepsy [ILAE] (2005-2009), Chair of the Diagnostic Commission of ILAE (2009-2013), coordinator of the Postgraduate Subcommittee of the Medical Physiopathology course at FCM-UNICAMP (2006-2010), head of the Department of Neurology at FCM-Unicamp (2002-2006, 2010-2020, and 2022-2024), and Coordinator of the Research Chamber of FCM-UNICAMP (2008-2014).
He has published 580 full articles in specialized journals (534 on PubMed), 94 book chapters, and 13 books. He has supervised 28 master’s theses, 51 doctoral theses, 21 post-doctoral studies, and supervised 59 scientific initiation projects. H-index of 68 on Web of Science and 90 on Google Scholar.
He is a member of the editorial board of international scientific journals Neurology; Epilepsy Research; Arquivos de Neuropsiquiatria; and Associate Editor of the journal Epilepsia and Editor of Frontiers of Neurology Epilepsy.
He is a full member of the Brazilian Academy of Sciences, the Brazilian Academy of Neurology, the Brazilian Society of Clinical Neurophysiology, and the Brazilian Society of Diagnostic and Therapeutic Neuroradiology.
He is an associate member of the American Academy of Neurology and the American Epilepsy Society.
Professor Titular do Departamento de Neurologia da UNICAMP.
Em 1997 ingressou como médico e docente na Faculdade de Ciências Médicas da Unicamp.
É professor visitante da Universidade McGill, Departamento de Neurologia e Neurocirurgia (desde 1997) e foi dos coordenadores da área de saúde da FAPESP (2007-2021).
Foi presidente da Liga Brasileira de Epilepsia (2006-2008), secretário da Subcomissão de Neuroimagem da Liga Internacional Contra a Epilepsia [ILAE] (2005-2009), Chair da Diagnostic commission da ILAE (2009-2013), coordenador da Subcomissão de Pós-Graduação do curso de Fisiopatologia Médica da FCM-UNICAMP (2006-2010), chefe do Departamento de Neurologia da FCM-Unicamp (2002-2006, 2010-2020 e 2022-2024) e Coordenador da Câmara de Pesquisa da FCM-UNICAMP (2008-2014).
Publicou 580 artigos completos em periódicos especializados (534 no Pubmed), 94 capítulos de livros e 13 livros. Orientou 28 dissertações de mestrado, 51 teses de doutorado, 21 pós-doutorados, além de ter orientado 59 trabalhos de iniciação científica. Índice H 68 no Web of Science e 90 no Google Scholar.
É membro de corpo editorial dos jornais científicos internacionais Neurology; Epilepsy Research; Arquivos de Neuropsiquiatria; e Editor Associado do jornal Epilepsia e Editor do Frontiers of Neurology Epilepsy.
É membro titular da Academia Brasileira de Ciências, da Academia Brasileira de Neurologia, da Sociedade Brasileira de Neurofisiologia Clínica e da Sociedade Brasileira de Neuroradiologia Diagnóstica e Terapêutica.
É membro associado da American Academy of Neurology e da American Epilepsy Society.
Iscia Lopes-Cendes
Three Decades of Research on the Genetics of Epilepsy: My Personal Scientific Journey
Lecture on Friday, April 5th, 10:20am to 11:00am
She holds a degree in Medicine from the State University of Campinas (1987), completed her Medical Residency in Pediatrics at the State University of Campinas (1990), obtained a Master’s degree in Neurosciences from McGill University, Canada (1993), a Ph.D. in Neurosciences from McGill University, Montreal, Canada (1999), a Livre Docência from the State University of Campinas (2003), and became a Full Professor at the State University of Campinas (2009).
Currently, she is the Head of the Molecular Genetics Laboratory at FCM-UNICAMP.
She is the author of more than 255 scientific articles in specialized journals and has supervised over 50 theses and dissertations, including more than 31 doctoral theses.
She is part of research groups in Epilepsy and Neuroimaging and coordinates the Neurogenetics Research Group.
She is the principal researcher of the Brazilian Institute of Neuroscience and Neurotechnology and a member of the Management Committee of the Brazilian Initiative of Precision Medicine (www.bipmed.org).
She has received several national and international awards for her contributions to research on epilepsy and neurodegenerative diseases.
She provides community services at the outpatient clinics of the Clinical Genetics and Neurology services at HC-Unicamp.
She is an elected member of the Brazilian Academy of Sciences (ABC) and the Academy of Sciences of the State of São Paulo (ACIESP).
Possui graduação em Medicina pela Universidade Estadual de Campinas (1987), Residência Médica em Pediatria pela Universidade Estadual de Campinas (1990), Mestrado em Neurociências pela Mcgill University, Canadá (1993); Doutorado em Neurociências pela Mcgill University, Montreal, Canadá (1999) , Livre Docência pela Universidade Estadual de Campinas (2003) e Professor Titular pela Universidade Estadual de Campinas (2009).
Atualmente é Chefe do Laboratório de Genética Molecular da FCM-UNICAMP.
É autora de mais de 255 artigos científicos em periódicos especializados. Já orientou mais de 50 teses e dissertações, sendo mais de 31 teses de doutorado.
Integra os grupos de pesquisa em Epilepsia e Neuroimagem e coordena o Grupo de Pesquisa em Neurogenética.
É pesquisadora principal do Brazilian Instituto of Neuroscience and Neurotecnology e membro do Comitê Gestor da Brazilian Initiative of Precision Medicine (www.bipmed.org).
Já recebeu vários prêmios nacionais e internacionais por sua contribuição na pesquisa sobre as epilepsias e doenças neurodegenerativas.
Presta serviços à comunidade nos ambulatórios dos serviços de Genética Clínica e Neurologia do HC-Unicamp.
É membro eleito da Academia Brasileira de Ciências (ABC) e da Academia de Ciências do Estado de São Paulo (ACIESP).
Lília Freire Rodrigues de Souza Li
Lecture on Friday, April 5th, 09:00am to 09:40am
Dr. Lília holds a degree in Medicine from the Federal University of Paraná (1989), with specialization titles in Pediatrics (1993), Pediatric Endocrinology (2004), and Adolescent Medicine (2007). She completed her Doctorate in Experimental Medicine at McGill University, Canada (2000), and a Postdoctoral fellowship at Harvard Medical School, USA (2016).
She coordinated the Pediatric Endocrinology Laboratory at the Center for Pediatric Investigation (CIPED), FCM, UNICAMP, from 2001 to 2019.
Since 2005, she has been the responsible professor for the Adolescent Medicine Discipline in the Department of Pediatrics at the State University of Campinas.
She was the coordinator of the Graduate Program in Child and Adolescent Health at the Faculty of Medical Sciences of UNICAMP (2010-2014) and a Visiting Scientist in the Department of Developmental Medicine at Boston Children’s Hospital and a Visiting Assistant Professor in the Department of Pediatrics, Harvard Medical School, Boston, USA, from July 2014 to June 2016.
She has expertise in the field of Medicine, with emphasis on Pediatrics, Adolescent Medicine, and Pediatric Endocrinology, focusing primarily on topics such as Neuroeducation, community intervention for adolescent risk prevention, and bone-metabolic diseases.
Possui graduação em Medicina pela Universidade Federal do Paraná (1989), título de Especialista em Pediatria (1993), em Endocrinologia Pediátrica (2004), e em Medicina do Adolescente (2007). Fez seu Doutorado em Experimental Medicine pela McGill University, Canadá (2000) e Pós-Doutorado na Harvard Medical School, EUA (2016).
Coordenou o Laboratório de Endocrinologia Pediátrica do Centro de Investigação em Pediatria (CIPED), FCM, UNICAMP, de 2001 a 2019.
Desde 2005 é Professora responsável pela Disciplina de Medicina do Adolescente do Departamento de Pediatria da Universidade Estadual de Campinas.
Foi coordenadora do Programa de Pós-Graduação em Saúde da Criança e do Adolescente da Faculdade de Ciências Médicas da UNICAMP (2010-2014) e Cientista Visitante no Departamento de Developmental Medicine do Boston Children’s Hospital e Professora Assistente Visitante do Department of Pediatrics, Harvard Medical School, Boston, EUA de julho de 2014 a junho de 2016.
Tem experiência na área de Medicina, com ênfase em Pediatria, Medicina do Adolescente e Endocrinologia Pediátrica atuando principalmente nos seguintes temas: Neuroeducação, intervenção comunitária para prevenção de risco na adolescência e doenças ósseo-metabólicas.
Matthias Van Osch
Non-invasive brain clearance imaging
Lecture on Thursday, April 4th, 11:30am to 12:30pm
Matthias van Osch is professor in Radiology, experimental cerebrovascular imaging and he is vice-director of the C.J. Gorter Center for high field MRI. In 2016 he was awarded with the innovational research incentives scheme VICI “Breaking through spatial, temporal and physiological boundaries in brain imaging”.
Cerebrovascular imaging
The human brain has limited storage capacity for oxygen and nutrients and is therefore critically dependent on a continuous influx of blood to deliver these. In most brain diseases, afflictions of the cerebral vessels and/or impaired cerebral blood flow are thought to be important contributors. To characterize disease stage, allow early detection, and especially to monitor treatment efficacy, it is important to be able to measure cerebral perfusion as well as to probe the microvascular health. By developing new magnetic resonance imaging (MRI) sequences Matthias van Osch wants to enable such imaging technologies.
Although individual cerebral capillaries are too small to be imaged at the moment with any in vivo medical modality, MRI allows to magnetically labeling of the water in blood and monitor its inflow into the tissue, thereby providing a map of cerebral perfusion in a quantitative fashion. Importantly, this is a completely safe and non-invasive approach. By expanding on this technological approach, Matthias van Osch wants to enable imaging of other cerebrovascular parameters, such as oxygenation and subtle blood-brain-barrier damage, as well as microvascular health in general (measurements done with a typical pixel-size of 3x3x3 mm). Subsequently, these techniques will be clinically validated and applied. Interactions between brain perfusion and systemic processes such as heart function, will be an important applied research topic.
Matthias van Osch é professor de Radiologia, especializado em imagem cerebrovascular experimental, e vice-diretor do Centro C.J. Gorter para Ressonância Magnética de Alto Campo. Em 2016, foi agraciado com o esquema de incentivos à pesquisa inovadora VICI “Transpondo barreiras espaciais, temporais e fisiológicas na imagem cerebral”.
Imagem cerebrovascular
O cérebro humano possui capacidade limitada de armazenamento de oxigênio e nutrientes, sendo, portanto, criticamente dependente de um influxo contínuo de sangue para entregá-los. Na maioria das doenças cerebrais, afecções dos vasos cerebrais e/ou fluxo sanguíneo cerebral prejudicado são considerados contribuintes importantes. Para caracterizar o estágio da doença, permitir a detecção precoce e, especialmente, monitorar a eficácia do tratamento, é importante poder medir a perfusão cerebral e sondar a saúde microvascular. Desenvolvendo novas sequências de imagem por ressonância magnética (MRI), Matthias van Osch deseja possibilitar essas tecnologias de imagem.
Embora os capilares cerebrais individuais sejam muito pequenos para serem visualizados no momento com qualquer modalidade médica in vivo, a MRI permite a marcação magnética da água no sangue e o monitoramento de seu influxo no tecido, fornecendo assim um mapa da perfusão cerebral de maneira quantitativa. Importante destacar que esta abordagem é completamente segura e não invasiva. Expandindo essa abordagem tecnológica, Matthias van Osch quer possibilitar a imagem de outros parâmetros cerebrovasculares, como oxigenação e danos sutis à barreira hematoencefálica, bem como a saúde microvascular em geral (medidas feitas com um tamanho típico de pixel de 3x3x3 mm). Posteriormente, essas técnicas serão validadas e aplicadas clinicamente. As interações entre a perfusão cerebral e processos sistêmicos, como a função cardíaca, serão um importante tópico de pesquisa aplicada.
Daniel Papoti
Advances in RF coil technology for preclinical MRI at 9.4 Teslas
Lecture on Wednesday, April 3rd, 11:00am to 12:00pm
He is currently an adjunct Professor in the Biomedical Engineering course at the Federal University of ABC. He holds a bachelor’s degree in physics from USP-São Carlos (2003) with a master’s degree in physics (2006) and a doctorate in applied physics (2011) from the same institution. He completed a postdoctoral period at the Cerebral Microcirculation Unit, at the National Institute of Neurological Disorders and Stroke, NIH, in Maryland (USA). He has experience in Physics, with an emphasis on instrumentation for Magnetic Resonance Imaging, working mainly on the development of radiofrequency coils and pre-amplifiers for MRI.
Atualmente é professor adjunto no curso de engenharia biomédica da Universidade Federal do ABC, em São Bernardo do Campo. Possui graduação em bacharelado em física pela USP-São Carlos (2003) com mestrado em física básica (2006) e doutorado em física aplicada (2011) pela mesma instituição. Realizou período de pós-doutorado junto ao Cerebral Microcirculation Unit, no National Institute of Neurological Disorders and Stroke, NIH, em Maryland nos Estados Unidos. De 2022 a 2023 trabalhou como Visiting Research Assistant Professor no Department of Neurobiology, na University of Pittsburgh. Tem experiência na área de Física, com ênfase em instrumentação de radiofrequência para Imagens por Ressonância Magnética, atuando principalmente no desenvolvimento de bobinas de RF transmissoras, bobinas receptoras multicanais e pré-amplificadores para MRI.
Afonso Costa e Silva
Generation, Characterization, and Validation of Marmoset Models of Alzheimer’s Disease
Lecture on Wednesday, April 3rd, 11:30am to 12:30pm
Professor Afonso has over 30 years of experience developing magnetic resonance
imaging methods to investigate the anatomical and functional organization of the
brain. He is a Member of the International Society for Magnetic Resonance in Medicine (ISMRM), of the International Society for Cerebral Blood Flow and Metabolism (ISCBFM), of the Society for Neuroscience (SFN), and of The American Association for the Advancement of Science (AAAS). His articles have over 13.7 thousand citations, with an h-Index of 68.
Short bio (from his profile at the University of Pittsburgh website):
“We are interested in using a combination of behavioral, electrophysiological and imaging techniques to understand the mechanisms of neurovascular coupling that maintain a tight relationship between neuronal activity and cerebral blood flow. This relationship is crucial for the brain, and its disruption leads to dysfunction and disease. Our main research interests are in understanding mechanisms of cerebrovascular dysfunction as a common cause of several neurodegenerative diseases. We have extensive experience in the development and application of multimodal neuroimaging methods to study the brain’s anatomy and function, and our laboratory works with genetically engineered marmoset models of brain diseases, including stroke, Alzheimer’s disease and multiple sclerosis. Our expertise is in the development of functional neuroimaging methods to understand (1) how the cerebral microvasculature reacts, in space and in time, to changes in neuronal activity; and (2) to understand how the mechanisms of neurovascular coupling are disrupted in neurological disorders”.
Dr. Afonso Costa e Silva possui mais de 30 anos de experiência no desenvolvimento de métodos de imagem por ressonância magnética para investigar a organização anatômica e funcional do cérebro. Ele é membro da Sociedade Internacional de Ressonância Magnética em Medicina (ISMRM), da Sociedade Internacional de Fluxo Sanguíneo Cerebral e Metabolismo (ISCBFM), da Sociedade de Neurociência (SFN) e da Associação Americana para o Avanço da Ciência (AAAS). Seus artigos possuem mais de 13,7 mil citações, com um índice h 68.
Breve biografia (de seu perfil no website da Universidade de Pittsburgh):
“Estamos interessados em utilizar uma combinação de técnicas comportamentais, eletrofisiológicas e de imagem para compreender os mecanismos de acoplamento neurovascular que mantêm uma relação estreita entre a atividade neuronal e o fluxo sanguíneo cerebral. Essa relação é crucial para o cérebro, e sua interrupção leva a disfunções e doenças. Nossos principais interesses de pesquisa estão em compreender os mecanismos da disfunção cerebrovascular como uma causa comum de várias doenças neurodegenerativas. Possuímos uma vasta experiência no desenvolvimento e aplicação de métodos de neuroimagem multimodais para estudar a anatomia e função do cérebro, e nosso laboratório trabalha com modelos de marmoset geneticamente modificados para doenças cerebrais, incluindo acidente vascular cerebral, doença de Alzheimer e esclerose múltipla. Nossa especialidade está no desenvolvimento de métodos de neuroimagem funcional para compreender (1) como a microvasculatura cerebral reage, no espaço e no tempo, a mudanças na atividade neuronal; e (2) entender como os mecanismos de acoplamento neurovascular são prejudicados em distúrbios neurológicos”.
Sponsors
Neuroscience to improve Latin American Identity. Scientific questions and experimental designs for the development of culture, behavior, perception and Latin American consciousness.
We are Epistemic, a startup that develops tools using technology to achieve our main objective: improving the lives of patients with epilepsy and their families.
The Brazilian Epilepsy League (LBE, in Portuguese) is an association that brings together medics and other professionals dedicated to the treatment of epilepsy patients.
Support
